Calibrum — the AI TRT coach that actually helps you balance your hormones

Adult men with clinically diagnosed low testosterone managing prescribed TRT under physician supervision. Patients of conventional urology and endocrinology practices, plus telehealth TRT providers (Hone Health, Hims, Maximus, Marek Health, TRT Nation, Defy Medical, and others). Men curious whether they are TRT candidates can use the free Vermeulen Free T calculator without subscribing. Not built for bodybuilders, enhanced athletes, off-label cycling, or grey-market testosterone sourcing.

No. Calibrum is an educational companion app. It does not diagnose, prescribe, treat, or recommend dose changes. It surfaces publicly available clinical guidelines from the Endocrine Society, AUA, and AAFP and helps you prepare for conversations with your prescriber. All medical decisions belong to you and your physician.

No. Calibrum does not recommend dose changes under any circumstances. Dose decisions involve labs, symptoms, comorbidities, and physician judgment that no app can responsibly substitute for. What Calibrum does is surface trend patterns, symptom-vs-lab correlations, and guideline-based context so your prescriber appointment is more productive.

No. The AI Hormone Coach is an education and reference layer, not a medical provider. It cites the same clinical guidelines your endocrinologist or urologist references but it is not licensed to diagnose, prescribe, or treat. For any actual medical decision — starting TRT, adjusting dose, adding anastrozole, addressing hematocrit, managing PSA changes — consult your prescriber.

The Coach answers TRT-related questions 24/7 using publicly available clinical guidance. Every reply cites the underlying source — Endocrine Society 2018 clinical practice guideline (Bhasin et al.), AUA testosterone deficiency evaluation algorithms, AAFP TRT monographs, FDA prescribing information for testosterone products and ancillaries, or peer-reviewed studies. The Coach does not generate personalized medical advice and does not recommend dose adjustments. It surfaces what the guidelines say so you can have a more informed conversation with your prescriber.

Reddit aggregates patient experiences, which is valuable for community and emotional support but inconsistent in clinical accuracy. The AI Hormone Coach cites peer-reviewed and society-published sources on every reply. Reddit is great for "did anyone else feel this way on week three" — Calibrum is built for "what does the Endocrine Society guideline say about hematocrit thresholds." Both have a place. Many users use both.

Photograph your LabCorp or Quest report, or import the PDF directly. On-device OCR handles cleanly formatted reports. For complex multi-column or low-resolution scans, only the cropped marker region is routed through a privacy proxy to an AI vision model for text extraction. You review every extracted value before saving — nothing is auto-recorded. Supported markers include Total Testosterone, Free Testosterone, SHBG, Estradiol (E2 ultrasensitive recommended), Hematocrit, Hemoglobin, PSA, and standard CBC/CMP values.

On clean LabCorp and Quest PDF reports, very high — these labs use consistent formatting. On photos with poor lighting, glare, or skewed angle, accuracy degrades. The app always shows you the extracted values before saving so you can correct any errors. Treat Lab Snap as a fast first pass, not as a substitute for visually checking your numbers.

Yes, permanently free, no subscription required. The calculator uses the Vermeulen formula — the gold-standard equation for estimating Free T and Bioavailable T from Total T, SHBG, and albumin. Enter the three values from your lab report, the calculator returns Free T and Bioavailable T in your preferred units. No data leaves your device. We put this in the free tier because Free T calculation is essential information that should not be paywalled.

You log symptoms — bloat, nipple sensitivity, mood swings, libido changes, joint pain, water retention, headache. The triage system maps your symptom pattern against published symptom profiles for high-E2 vs low-E2 vs unrelated-to-E2 conditions, weighted against your most recent measured E2 value and estimated medication timing curve. The output is a triage summary: pattern suggests high E2, pattern suggests low E2, pattern not clearly E2-related, or insufficient data. It is a starting point for the conversation with your prescriber, not a verdict.

A one- to two-page summary covering the last 90 days. Section 1: dose history with any changes and the protocol you are running. Section 2: symptom trend chart (energy, libido, mood, sleep, sexual function) with notable shifts highlighted. Section 3: lab summary with key markers and trend arrows. Section 4: three to five personalized questions to ask your prescriber, generated from any flagged patterns. You can export, print, or share via your phone's standard share sheet.

No, and we will not add this in future versions. Aromatase inhibitor dosing is a clinical decision that depends on your specific labs, symptoms, and physician judgment. Over-suppressing E2 with anastrozole causes its own set of problems (joint pain, lipid changes, mood issues, sexual dysfunction) that are arguably worse than mildly elevated E2. Calibrum surfaces the triage and the question set; your prescriber makes the call.

These are documented considerations and Calibrum surfaces published guidance on both. Hematocrit above 54% is the thrombotic risk threshold flagged in the Endocrine Society guidelines and Lab Snap triggers an explicit warning when this is exceeded. PSA trend monitoring is included with AUA prostate surveillance protocol context. For any concerning value — severe hematocrit elevation, rapid PSA velocity, chest pain, severe edema — call your prescriber or 911 immediately, regardless of what any app shows.

No. All your data — doses, lab values, symptom logs, lab report photos — stays locally on your device. Lab Snap occasionally routes a cropped image through a privacy proxy when on-device OCR fails on complex layouts; that image is processed and discarded, never stored or linked to your identity. No account is required. No analytics tied to identity. No data is sold.

Yes. Calibrum works as a personal tracking and education tool regardless of where your prescription comes from. Common usage patterns include patients of Hone Health, Hims, Maximus, Marek Health, TRT Nation, Defy Medical, conventional urology offices, and primary care providers. Calibrum is not affiliated with, endorsed by, or sponsored by any TRT clinic. We have zero commercial relationship with any provider.

Yes. Calibrum supports the common TRT routes — IM weekly, twice-weekly, SubQ daily, gels (AndroGel®, Testim®, Fortesta®), pellets (Testopel®), and oral options (Jatenzo®, Kyzatrex®). The Smart Bloodwork Timing calculates retest windows based on the medication's published half-life, which varies significantly across routes.

Yes, as an ancillary medication. The Smart Injection Tracker supports hCG with separate scheduling. The AI Hormone Coach can answer questions about hCG use alongside TRT based on publicly available guidance — fertility preservation, testicular atrophy considerations, dosing concepts. As with all medications, the actual dose and decision belong to your prescriber.

This is a real consideration — exogenous testosterone suppresses endogenous testicular function and can affect fertility. Calibrum surfaces the standard publicly available guidance on hCG, enclomiphene, and related fertility-preservation strategies, and tracks ancillary medications used for this purpose. For active fertility planning, see a reproductive endocrinologist. Calibrum does not replace that consultation.

Yes. Weight, blood pressure, and certain biomarker readings can sync from Apple Health into Calibrum's trend charts. You control what data flows in and what stays in Calibrum only. Lab values you enter manually or via Lab Snap stay in Calibrum unless you explicitly export.

HIPAA applies to covered entities (providers, insurers, business associates) — not directly to consumer wellness apps that you use yourself. Practically, Calibrum keeps your data on your device, requires no account, and minimizes server-side data flow. If you choose to share a Doctor Visit Prep PDF with your prescriber, that becomes part of your medical record under their HIPAA obligations.

Calibrum's clinical guidance content is currently built around male hypogonadism management as defined in the Endocrine Society and AUA guidelines for cis men. The injection tracking, lab tracking, and Free T calculator work in any context, but the E2 symptom triage and clinical-context features are framed for cis male TRT. For gender-affirming care apps with community and milestone tracking, Transcapsule and similar apps may serve those use cases better.

If you do not cancel, the trial converts to your selected paid plan — $4.99/week or $49.99/year. You can cancel any time at least 24 hours before the renewal date in iPhone Settings → Apple ID → Subscriptions. After cancellation you keep access until the end of the current billing period, then the subscription features become unavailable. The Free Testosterone Calculator continues working forever in the free tier.

App Store subscription refunds are handled by Apple, not by Calibrum directly. Request a refund through reportaproblem.apple.com or via your iPhone Settings → Apple ID → Subscriptions. Apple generally honors refund requests for subscriptions cancelled shortly after auto-renewal.